Capsugel® DBcaps® Over-Encapsulation Capsules

Assuring the integrity of blind clinical trials

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Accommodates over-encaspulation of 90% of marketed solid dosage forms

Speeds up blinding process for faster time-to-clinic

Dual features including dual locking ring and double layer of opaque material

Designed specifically for double-blind studies

DBcaps® over-encapsulation capsules are developed with a tamper-evident and easy-to-swallow design to specifically address the clinical trial challenges of testing without bias.

For technical and quality specifications, please refer to our Technical Reference File below.

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Product features

Patented locking mechanism to ensure the integrity of the blind
Wider diameter allowing containment and blinding of large-diameter or uniquely-shaped tablets or other comparator products
Shorter length for easy swallowing
Available as gelatin or HPMC, in a wide range of sizes

Helping you meet the most stringent pharmaceutical standards for your clinical trial phase

DBcaps® Over-Encapsulation Capsules help optimize your process while improving patient compliance during clinical trials.

*Certifications may vary by site

Product features

GMP
ISO
EXCiPACT
Kosher
Halal
Non-GMO
BSE/TSE compliant

Partnering beyond the capsule

Offering unique capsule customization services, our Innovaform® Accelerator center experts will work with you to find a solution supporting your next development to full-scale manufacturing.

Service features

Ability to adapt your study to the blinding form characteristics
Bring your product to market faster with no change in dosage form properties
Can be used on a wide choice of capsule filling machines for an easy blinding process

Capsules that allow for easy and efficient blinding during clinical trials

Develop your drug faster with capsules designed for the R&D stage. Ensure patient compliance and eliminate bias with double-blind capsules for clinical trials.

Product features

Double-blind clinical trials
Comparator studies without dosage form modification
CNS trials

Supporting Documents

Webinar (on-demand)

DBcaps® Double Blind. Zero Bias.

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Frequently Asked Questions

Capsugel® DBcaps® capsules are available in 8 sizes in gelatin and 3 sizes in hypromellose (HPMC). Our broad offer helps address the bioavailability and formulation challenges of oral solid dosage forms that need to be blinded for clinical trials. HPMC provides an excellent solution for hygroscopic filling as well as a dissolution performance that is maintained with formulations usually prone to promote cross-linking with gelatin.

Yes, the extended cap length of Capsugel® DBcaps® capsules completely covers the side wall of the capsule body, making it virtually impossible to open the capsule without causing visible damage. A dual locking ring design provides a full-circumference, leak-free closure.

Capsugel® DBcaps® capsules can be filled on most automatic and semi-automatic capsule filling machines, as well as on selected manual filling machines. For your convenience, the Lonza Engine™ equipment portfolio contains options for efficient over-encapsulation manufacturing of clinical batches.

Capsugel® DBcaps® are uniquely designed for double-blind clinical trials. Capsugel® DBcaps® capsules are shorter than standard size capsules, making them easier to swallow.

Capsugel® DBcaps® capsules can be ordered in any quantity and are also available in a convenient CapsuleCaddy™ Container, perfect for clinical trial batches and R&D projects.

Capsugel® DBcaps® are uniquely designed for double-blind clinical trials. Capsugel® DBcaps® are available in 8 sizes in gelatin and 3 sizes in hypromellose (HPMC), these sizes allow to encapsulate up to 90% of the most common tableted drugs.